The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism.

ABSTRACT:

Background

The emerging incidence of pathogenic liver conditions is turning into a major concern for global health. Induction of pyroptosis in hepatocytes instigates cellular disintegration, which in turn liberates substantial quantities of pro-inflammatory intracellular substances, thereby accelerating the advancement of liver fibrosis. Consequently, directing therapeutic efforts towards inhibiting pyroptosis could potentially serve as an innovative approach in managing inflammation related chronic hepatic disorders.

Methods

GSDMD-NT^ki/wt mice and Alb-cre^ki/wt mice were generated using CRISPR/Cas9 technology. After crossing the two strains together, we induced conditional cell death by doxycycline to construct a mouse model of liver fibrosis. We analyz

SUBMITTER: Wang X 

PROVIDER: S-EPMC11798734 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature