The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes.

ABSTRACT:

Background

Over the past few decades, a threefold increase in obesity and type 2 diabetes (T2D) has placed a heavy burden on the health-care system and society. Previous studies have shown correlations between obesity, T2D, and neurodegenerative diseases, including dementia. It is imperative to further understand the relationship between obesity, T2D, and cognitive deficits.

Methods

This investigation tested and evaluated the cognitive impact of obesity and T2D induced by high-fat diet (HFD) and the effect of the host genetic background on the severity of cognitive decline caused by obesity and T2D in collaborative cross (CC) mice. The CC mice are a genetically diverse panel derived from eight inbred strains.

Results

Our findings demonstrated significant variations in

SUBMITTER: Paz A 

PROVIDER: S-EPMC11798739 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature