Exploring genetic structures and shared sites between alcohol, cheese intake, and inflammatory bowel disease.

ABSTRACT:

Background

An association has been observed between alcohol and cheese intake and the onset of inflammatory bowel disease (IBD), necessitating further exploration from a genetic structural perspective.

Methods

The present analysis was focused on the intake of alcohol and cheese in conjunction with IBD genome-wide association study (GWAS) data, with the objective of exploring genetic correlations and identifying common loci. Initially, overall genetic correlations were assessed employing two methodologies: linkage disequilibrium score regression (LDSC) and genetic covariance analyzer (GNOVA). Subsequently, local correlations were examined through the SUPERGNOVA method. A genetic overlap analysis between various traits was then conducted based on the statistical theory of cond

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11798781 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature