Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome.

ABSTRACT:

Purpose

PEXS was first described in 1917, yet its etiology still needs clarification. An imbalance between oxidants and antioxidants plays a significant role. PEXS leads to various ocular complications, including increased risk during cataract surgery due to weak zonules, lens dislocation, and reduced visual outcomes. Our study investigates whether metabolomics can provide insights into this ocular pathology.

Methods

The study included 183 patients undergoing cataract surgery at Pauls Stradins Clinical University Hospital. 104 patients did not have PEXS, while 79 were diagnosed with the condition. Intraocular fluid samples from these patients were analyzed using targeted metabolite analysis, performed through HILIC liquid chromatography coupled with mass spectrometry detecti

SUBMITTER: Zemitis A 

PROVIDER: S-EPMC11798801 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature