Beta-hydroxy-beta-methyl butyrate supplementation in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Beta-hydroxy-beta-methylbutyrate (HMB) is beneficial for restoring muscle mass. However, the evidence supporting its use in critically ill patients remains unclear. We conducted a systematic review and meta-analysis of HMB in this population to ascertain its effects.

Methods

We searched PubMed, Embase, China National Knowledge Infrastructure, Wanfang, and the Cochrane database for articles focusing on adult patients receiving HMB compared to controls. The primary outcome was mortality. To explore potential heterogeneity, we assessed study quality and performed subgroup analysis, sensitivity analysis, and quality of evidence.

Results

Nine randomized controlled trials were included. There were some differences in the study design, HMB protocols, and muscle me

SUBMITTER: Ren Y 

PROVIDER: S-EPMC11798817 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature