Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.

ABSTRACT: Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function^1,2. Mammalian brains consist of thousands of cell types³, which may be differentially susceptible or resilient to ageing. Here we present a comprehensive single-cell RNA sequencing dataset containing roughly 1.2 million high-quality single-cell transcriptomes of brain cells from young adult and aged mice of both sexes, from regions spanning the forebrain, midbrain and hindbrain. High-resolution clustering of all cells results in 847 cell clusters and reveals at least 14 age-biased clusters that are mostly glial types. At the broader cell subclass and supertype levels, we find age-associated gene expression signatures and provide a list of 2,449 u

SUBMITTER: Jin K 

PROVIDER: S-EPMC11798837 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature