The maternal X chromosome affects cognition and brain ageing in female mice.

ABSTRACT: Female mammalian cells have two X chromosomes, one of maternal origin and one of paternal origin. During development, one X chromosome randomly becomes inactivated^1-4. This renders either the maternal X (X_m) chromosome or the paternal X (X_p) chromosome inactive, causing X mosaicism that varies between female individuals, with some showing considerable or complete skew of the X chromosome that remains active^5-7. Parent-of-X origin can modify epigenetics through DNA methylation^8,9 and possibly gene expression; thus, mosaicism could buffer dysregulated processes in ageing and disease. However, whether X skew or its mosaicism alters functions in female individuals is largely unknown. Here we tested whether skew towards an active X_m

SUBMITTER: Abdulai-Saiku S 

PROVIDER: S-EPMC11798838 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature