Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia.

ABSTRACT:

Background

The involvement of mitochondrial and programmed cell death (mtPCD)-related genes in the pathogenesis of pre-eclampsia (PE) remains inadequately characterized.

Methods

This study explores the role of mtPCD genes in PE through bioinformatics and experimental approaches. Differentially expressed mtPCD genes were identified as potential biomarkers from the GSE10588 and GSE98224 datasets and subsequently validated. Hub genes were determined using support vector machine, least absolute shrinkage and selection operator, and Boruta based on consistent expression profiles. Their performance was assessed through nomogram and artificial neural network models. Biomarkers were subjected to localization, functional annotation, regulatory network analysis, and drug prediction. C

SUBMITTER: Lin R 

PROVIDER: S-EPMC11798957 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature