Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain.

ABSTRACT:

Introduction

Neurosphere culture is widely used to expand neural stem and progenitor cells (NSPCs) of the nervous system. Understanding the identity of NSPCs, such as the principals involved in spatiotemporal patterning, will improve our chances of using NSPCs for neurodevelopmental and brain repair studies with the ability to direct NSPCs toward distinct fates. Some reports indicate that aging can affect the nature of NSPCs over time. Therefore, in this study, we aimed to investigate how the initial neural patterning of developing NSPCs changes over time.

Methods

In this research, evidence of changing neural patterning potential in the nervous system over time was presented. Thus, the embryonic and adult-derived NSPCs for cardinal characteristics were analyzed, and then, th

SUBMITTER: Aran S 

PROVIDER: S-EPMC11798963 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature