Predatory bacteria can intensify lung-injury in a multidrug-resistant <i>Acinetobacter baumannii</i> pneumonia model in rat.

ABSTRACT:

Introduction

Respiratory tract infection caused by antibiotic-resistant bacteria are one of the most important causes of death worldwide. Therefore, in this study, we investigated the possibility of using predatory bacteria to improve the Acinetobacter baumannii pneumonia model in rat.

Methods

Multidrug-resistant (MDR) A. baumannii clinical strain was used to induce pneumonia. In addition to the sham and predator control group, three treatment groups (n = 5) were studied with colistin, Bdellovibrio bacteriovorus HD100, and combination of predator and antibiotics. Also, the colistin MIC value for B. bacteriovorus HD100 (8 μg/mL) was determined for the first time to our knowledge. Removal of excess endotoxin from the predator suspension was p

SUBMITTER: Mohsenipour Z 

PROVIDER: S-EPMC11798975 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature