Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Introduction

The role of the chemokine CX3CL1 in the processes of aging and Alzheimer's disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients, those experiencing amnestic mild cognitive impairment (aMCI), and cognitively normal (CN) individuals.

Methods

A cohort comprising 516 CN individuals across various age groups, 102 AD patients, and 65 subjects with aMCI was assembled, alongside 93 age- and sex-matched CN controls. Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify urinary CX3CL1 levels.

Results

Urinary CX3CL1 concentrations exhibited an age-dependent increase and demonstrated a positive correlation with age. Comparatively, AD patients exh

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11798980 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature