Validation of quantitative [¹⁸F]NaF PET uptake parameters in bone diseases: a systematic review.

ABSTRACT:

Purpose

[¹⁸F]NaF PET has become an increasingly important tool in clinical practice toward understanding and evaluating diseases and conditions in which bone metabolism is disrupted. Full kinetic analysis using nonlinear regression (NLR) with a two-tissue compartment model to determine the net rate of influx (K_i) of [¹⁸F]NaF is considered the gold standard for quantification of [¹⁸F]NaF uptake. However, dynamic scanning often is impractical in a clinical setting, leading to the development of simplified semi-quantitative parameters. This systematic review investigated which uptake parameters have been used to evaluate bone disorders and how they have been validated to measure disease activity.

Methods

A literature search (in PubMed

SUBMITTER: de Ruiter RD 

PROVIDER: S-EPMC11799077 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature