Adenylate kinase 5 deficiency impairs epididymal white adipose tissue homeostasis and decreases fat mass.

ABSTRACT:

Importance

The brain and adipose tissue interact metabolically, and if there is a problem with the energy metabolism of the brain, it cannot maintain the energy balance with the adipose tissue. Therefore, when adenylate kinase 5 (AK5), which regulates energy metabolism in the brain, is knocked out, problems with lipid metabolism may occur.

Objective

We aimed to elucidate the metabolic function and phenotype of AK5, a gene with an unknown function in metabolism.

Methods

We generated AK5 knockout (KO) mice and administered high-fat and fasting diets to the mice to confirm their physiological phenotype and metabolic differences.

Results

In the high-fat diet (HFD) test, no differences in body weight, epididymal white adipose tissue (eWAT), or f

SUBMITTER: Hwang S 

PROVIDER: S-EPMC11799087 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature