CD24 flags anastasis in melanoma cells.

ABSTRACT: Anastasis is a phenomenon observed in cancer cells, where cells that have initiated apoptosis are able to recover and survive. This molecular event is increasingly recognized as a potential contributor to cancer metastasis, facilitating the survival and migration of tumor cells. Nevertheless, the identification of a specific surface marker for detecting cancer cells in anastasis remained elusive. Here we report our observation that the cell surface expression of CD24 is preferentially enriched in a non-adherent FSC^lowSSC^high melanoma subpopulation, which is generally considered a non-viable population in cultivated melanoma cell lines. More than 90% of non-adherent FSC^lowSSC^highCD24^+ve metastatic melanoma cells exhibited bonafide featu

SUBMITTER: Vasileva MH 

PROVIDER: S-EPMC11799124 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature