Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications.

ABSTRACT: Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. We also discuss how evolutionary game theory, coupled with contemporary molecular tools, may shed light on understudied mechanisms governing the dynamics of altruistic cooperation in cancer cells. Finally, we discuss h

SUBMITTER: Bin Masroni MS 

PROVIDER: S-EPMC11799181 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature