Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions.

ABSTRACT:

Objective

The cause of late-onset first epileptic seizures (LOFES) in older age is often not readily evident. In absence of probable causes, it has been suggested that cerebral small vessel disease (CSVD), which is common with increasing age, may be crucial. We aimed to further investigate the impact of white matter lesion (WML) burden and distribution pattern on LOFES.

Methods

We retrospectively compared structural MRI of LOFES patients (n = 39) aged 60 years or older to controls with a transient ischemic attack (TIA, n = 38) and to patient controls (n = 35). WML segmentation was performed on FLAIR images using the SPM based automated lesion prediction algorithm of the LST toolbox and careful manual adjustment. Further, a dichotomization of WML was achi

SUBMITTER: Nasca A 

PROVIDER: S-EPMC11799258 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature