Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain.

ABSTRACT: Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. In the present study, we evaluated the therapeutic efficacy of exosomes loaded with a nondegradable form of IκB (Exo-srIκB), which inhibits the nuclear translocation of NF-κB to suppress age-related neuroinflammation. Single-cell RNA sequencing revealed that

SUBMITTER: Lee CJ 

PROVIDER: S-EPMC11799301 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature