CD300E⁺ macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients.

ABSTRACT: Liver cirrhosis is prognostically associated with poor life expectancy owing to subsequent liver failure. Thus, understanding liver regeneration processes during cirrhotic injury is highly important. This study explored the role of macrophage heterogeneity in liver regeneration following splenectomy. We collected detailed clinical information from 54 patients with decompensated cirrhosis before and after splenectomy. Obvious liver regeneration was observed after splenectomy in cirrhotic patients. Single-cell RNA sequencing (scRNA-seq) was performed on three paired liver tissues from patients before and after surgery to explore the immune microenvironment map and the characteristics of liver regeneration-associated macrophages (RAMs). scRNA-seq analysis revealed that the composition of hepa

SUBMITTER: Yang T 

PROVIDER: S-EPMC11799435 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature