An unconstrained four pool model analysis of proton relaxation and magnetization transfer in ex vivo white matter.

ABSTRACT: Understanding proton relaxation in the brain's white matter remains an active field of magnetic resonance imaging research. Models of varying complexity have been proposed to link measurements to tissue composition/microstructure, in particular myelination. Although the presence of multiple aqueous and nonaqueous proton pools is well established experimentally, so-called "quantitative MRI" is usually based on simpler models due to the large number of model parameters. In this work, a comprehensive set of parameters characterizing a four-pool model is obtained. A piece of fixed porcine spinal-cord WM was investigated at 3 T and temperatures between 21 and 35 °C. Measurements included a wide range of preparations of the spin system in combination with long echo trains to achieve sensitivity

SUBMITTER: Wallstein N 

PROVIDER: S-EPMC11799436 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature