Simulation of Somatic Evolution Through the Introduction of Random Mutation to the Rules of Conway's Game of Life.

ABSTRACT:

Introduction

Conway's Game of Life (GOL), and related cellular automata (CA) models, have served as interesting simulations of complex behaviors resulting from simple rules of interactions between neighboring cells, that sometime resemble the growth and reproduction of living things. Thus, CA has been applied towards understanding the interaction and reproduction of single-cell organisms, and the growth of larger, disorganized tissues such as tumors. Surprisingly, however, there have been few attempts to adapt simple CA models to recreate the evolution of either new species, or subclones within a multicellular, tumor-like tissue.

Methods

In this article, I present a modified form of the classic Conway's GOL simulation, in which the three integer thresholds that define GOL (n

SUBMITTER: King MR 

PROVIDER: S-EPMC11799479 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature