Mechanical Trapping of the Cell Nucleus Into Microgroove Concavity But Not On Convexity Induces Cell Tissue Growth and Vascular Smooth Muscle Differentiation.

ABSTRACT:

Introduction

Vascular smooth muscle cells (VSMCs) in the normal aortic wall regulate vascular contraction and dilation. VSMCs change their phenotype from contractile to synthetic and actively remodel the aortic wall under pathological conditions. Findings on the differentiation mechanism of VSMCs have been reported in many in vitro studies; however, the mechanical environments in vivo aortic walls are quite different from those of in vitro culture conditions: VSMCs in vivo exhibit an elongated shape and form a tissue that aligns with the circumferential direction of the walls, whereas VSMCs in vitro spread randomly and form irregular shapes during cultivation on conventional flat culture dishes and dedifferentiate into a synthetic phenotype. To clarify the mechanisms underlying the

SUBMITTER: Nagayama K 

PROVIDER: S-EPMC11799480 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature