On the reduction of imaging time-points for dosimetry in radionuclide therapy.

ABSTRACT:

Background

The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes.

Methods

Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrated activities between measurement schemes when one or more time-points are removed were derived using the law of propagation of uncertainty for a population of time-activity-curve parameters. The formulae were derived under the assumptions of fixed coefficients of variation for estimated activities, and underlying mono-exponential curves. Analytical predictions were compared with resu

SUBMITTER: Gustafsson J 

PROVIDER: S-EPMC11799503 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature