Pancreatic organogenesis mapped through space and time.

ABSTRACT: The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a particular spatial organization. Signals from the mesenchyme, neurons, and endothelial cells instruct epithelial cell differentiation during pancreatic development. To understand the cellular diversity and spatial organization of the developing pancreatic niche, we mapped the spatial relationships between single cells over time. We found that four transcriptionally unique subtypes of mesenchyme in the developing pancreas spatially coordinate throughout development, with each subtype at fixed locations in sp

SUBMITTER: Scavuzzo MA 

PROVIDER: S-EPMC11799519 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature