A study on the codon usage bias of arenavirus common genes.

ABSTRACT:

Introduction

The Arenaviridae family consists of the genera Mammarenavirus, Reptarenavirus, Hartmanivirus, Antennavirus and Innmovirus. The codon usage bias between the different genera has not yet been studied comparatively.

Methods

We retrieved the arenavirus genome sequences from public databases and used bioinformatics tools to compare the codon usage bias between the different genera for the GPC, NP and L proteins, common to all arenaviruses.

Results and discussion

Hartmaniviruses show a larger codon usage bias, which can be partially explained by mutational bias. Patterns of relative use of synonymous codons were maintained within genera, with individual genera differing in their preference for the third nucleotide posit

SUBMITTER: Thomas PD 

PROVIDER: S-EPMC11799557 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature