Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study.

ABSTRACT:

Background

Whether there is a causal relationship between childhood obesity and increased risk of chronic kidney disease (CKD) remains controversial. This study sought to explore how body size in childhood and adulthood independently affects CKD risk in later life using a Mendelian randomization (MR) approach.

Methods

Univariate and multivariate MR was used to estimate total and independent effects of body size exposures. Genetic associations with early-life and adult body size were obtained from a genome-wide association study of 453,169 participants in the U.K. Biobank, and genetic associations with CKD were obtained from the CKDGen and FinnGen consortia.

Results

A larger genetically predicted early-life body size was associated with an increased risk of CKD (odds r

SUBMITTER: Li X 

PROVIDER: S-EPMC11799605 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature