Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing's syndrome.

ABSTRACT:

Background

Arterial hypertension and left ventricular hypertrophy and remodeling are independent cardiovascular risk factors in patients with Cushing's syndrome. Changes in the renin-angiotensin system and in the mineralocorticoid axis activity could be involved as potential mechanisms in their pathogenesis, in addition to cortisol excess.

Methods

In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing's syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and th

SUBMITTER: Wolf P 

PROVIDER: S-EPMC11799754 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature