Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos.

ABSTRACT: The transition of an embryo from gastrulation to organogenesis requires precisely coordinated changes in gene expression, but the underlying mechanisms remain unclear. The RNA-binding protein Trim71 is essential for development and serves as a potent regulator of post-transcriptional gene expression. Here, we show that global deficiency of Trim71 induces severe defects in mesoderm-derived cells at the onset of organogenesis. Murine Trim71-KO embryos displayed impaired primitive erythropoiesis, yolk sac vasculature, heart function, and circulation, explaining the embryonic lethality of these mice. Tie2 ^Cre Trim71 conditional knockout did not induce strong defects, showing that Trim71 expression in endothelial cells and their immediate progenitors is di

SUBMITTER: Beckroge T 

PROVIDER: S-EPMC11799773 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature