Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019.

ABSTRACT:

Background

Comparisons of nicotine and toxicant exposures between people who use different alternative tobacco products remain underexplored.

Methods

This cross-sectional, multicountry study analyzed urinary metabolites of nicotine, tobacco-specific nitrosamines [4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK)], and volatile organic compounds (acrolein, acrylamide, and acrylonitrile) among established users (n = 550) in Japan and Canada. Participants exclusively or concurrently used nicotine vaping products (NVP; Canada only), heated tobacco products (HTP; Japan only), and combustible cigarettes (CC; Japan and Canada) or abstained (Japan and Canada).

Results

All product groups showed substantial nicotine exposure. Both HTPs and NVPs exposed exclusive users to lower t

SUBMITTER: Miller CR 

PROVIDER: S-EPMC11799835 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature