Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage.

ABSTRACT:

Background

A substantial portion of the genetic predisposition for breast cancer is explained by multiple common genetic variants of relatively small effect. A subset of these variants, which have been identified mostly in individuals of European (EUR) and Asian ancestries, have been combined to construct a polygenic risk score (PRS) to predict breast cancer risk, but the prediction accuracy of existing PRSs in Hispanic/Latinx individuals (H/L) remain relatively low. We assessed the performance of several existing PRS panels with and without addition of H/L-specific variants among self-reported H/L women.

Methods

PRS performance was evaluated using multivariable logistic regression and the area under the ROC curve.

Results

Both EUR and Asian PRSs performed worse in H/

SUBMITTER: Huang X 

PROVIDER: S-EPMC11799839 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature