Ni-catalyzed regioselective and site-divergent reductive arylalkylations of allylic amines.

ABSTRACT: Catalytic methods by switching the least parameters for regioselective and site-divergent transformations to construct different architectures from identical and readily available starting materials are among the most ideal catalytic protocols. However, the associated challenge to precisely control both regioselectivity and site diversity renders this strategy appealing yet challenging. Herein, Ni-catalyzed cross-electrophile regioselective and site-divergent 1,2- and 1,3-arylalkylations of N-acyl allylic amines have been developed. This Ni-catalyzed reductive three-component protocol enables 1,2-arylalkylation and 1,3-arylalkylation of allylic amines with aryl halides and alkyl halides with excellent chemo-, regio- and site-selectivity, representing the first example of controlled

SUBMITTER: Meng H 

PROVIDER: S-EPMC11799853 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature