The Wheat NLR Protein PM3b Localises to Endoplasmic Reticulum-Plasma Membrane Contact Sites and Interacts With AVRPM3^b2/c2 Through Its LRR Domain.

ABSTRACT: Plant nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune receptors that directly or indirectly perceive pathogen-derived effector proteins to induce an immune response. NLRs display diverse subcellular localisations, which are associated with the capacity of the immune receptor to confer disease resistance and recognise its corresponding avirulence effector. In wheat, the NLR PM3b recognises the wheat powdery mildew effector AVRPM3^b2/c2 and we examined the molecular mechanism underlying this recognition. We show that PM3b and other PM3 variants localise to endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCS), while AVRPM3^b2/c2 localises to the nucleocytoplasmic space. Additionally, we found that PM3b interacts in planta with

SUBMITTER: Isaksson J 

PROVIDER: S-EPMC11799908 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature