MiR-448-3p/miR-1264-3p Participates in Intermittent Hypoxic Response in Hippocampus by Regulating Fam76b/hnRNPA2B1.

ABSTRACT:

Background

Intermittent hypoxia (IH), as a key pathogenic factor of obstructive sleep apnea syndrome (OSAS), can cause many diseases, such as increased inflammation and oxidative stress, diabetes, cardiovascular disease, and Alzheimer's disease (AD). The response of cells to hypoxia involves multiple levels of regulatory mechanisms, including transcriptional regulation of gene expression, regulation of mRNA stability, post-transcriptional regulation, and post-translational modification regulation.

Aims

The regulation of miRNA and alternative splicing (AS) in neuronal response to intermittent hypoxia deserve further study.

Materials & methods

By establishing a mouse model of intermittent hypoxia, we conducted functional studies on key miRNAs and splicing factor using m

SUBMITTER: Liu C 

PROVIDER: S-EPMC11799915 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature