In Silico Study of Pyrin and 14-3-3 Protein Modulation During FMF and PAAND.

ABSTRACT: Familial Mediterranean fever (FMF) is a genetically determined disease transmitted through autosomal recessive inheritance. Recently, a rare but similar disease to FMF, pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND), has been discovered. PAAND is inherited dominantly and is characterized by neutrophilic dermatosis and recurrent fevers. The cause of the disease is point mutations in the MEFV gene. The pyrin protein is a product of this gene and is one of the main factors in the disease's progression. This paper examines the interaction between pyrin and the 14-3-3 protein and screens for modulators affecting their interaction. Regulating this interaction is crucial for understanding the mechanism of FMF development, specifically the disruption of this complexation, w

SUBMITTER: Paronyan A 

PROVIDER: S-EPMC11799992 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature