Manganese-Catalyzed <i>N</i>-Formylation of Anilines Using Oxalic Acid as CO Surrogate.

ABSTRACT: Formanilides are valuable synthetic intermediates and additives in the rubber industry. Manganese-catalyzed N-formylation of aniline using (COOH)₂·2H₂O represents a significant advancement in the synthesis of formanilides. This novel approach offers a safe and efficient alternative to traditional carbon monoxide (CO) gas-based formylation reactions, addressing safety concerns and overcoming the challenges associated with handling gaseous CO. By employing (COOH)₂·2H₂O as a readily available and environmentally benign CO surrogate, this method also demonstrates the versatility of manganese catalysts in facilitating selective C-N bond formation. This study presents the first manganese-catalyzed synthesis of formanilides via the N-formy

SUBMITTER: Afsina CMA 

PROVIDER: S-EPMC11800000 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature