Infrared Spectroscopy Coupled with Machine Learning Algorithms to Investigate Vascular Dysfunction in Ovariectomy: An Animal Model Study.

ABSTRACT: A decrease in female sex hormone levels in the body impairs vascular endothelium functioning, leading to vascular dysfunction associated with certain diseases. Animal models of ovariectomy are commonly used to understand its effects on vascular (dys)function. Fourier-transform infrared (FTIR) spectroscopy is a technique capable of extracting detailed molecular information and, as such, has been applied to various biological analyses. This study evaluated systemic changes in the ovariectomy model using mid-infrared spectroscopy. Thirty-eight serum samples from adult Wistar rats were analyzed and divided into 18 in the control group (SHAM) and 20 in the ovariectomized group (OVX). Bilateral ovariectomy was performed, followed by euthanasia of the rats after 15 days. The spectral collection w

SUBMITTER: Travezani TS 

PROVIDER: S-EPMC11800005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature