Production and Characterization of Nanoparticulate Polyelectrolyte Complexes of Chitosan-Catechol, Ulvan, and Hyaluronic Acid.

ABSTRACT: This work provides the first description of the synthesis and characterization of polymeric nanoparticles (NPs) obtained by polyelectrolyte complexes (PECs) of three polysaccharides: chitosan (Cs) or its catecholic derivative, ulvan, and hyaluronic acid (HA). The carbodiimide method used catechol group conjugation onto the Cs backbone using the catechol-containing compound hydrocaffeic acid. A degree of substitution of 2.98% was determined by spectroscopy in the chitosan-catechol (CsC) conjugate. DLS studies showed hydrodynamic diameter (D _h) close to 300 nm for PECs of Cs and CsC with ulvan, with positive zeta potential for both complexes. HA coating was confirmed by obtaining negative zeta potential. The HA coating reduced the D _h values of the materia

SUBMITTER: Caro-Leon FJ 

PROVIDER: S-EPMC11800033 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature