Design of a Multi-Epitope Vaccine against the Glycoproteins of Newcastle Disease Virus by Using an Immunoinformatics Approach.

ABSTRACT: Newcastle disease (ND) causes major economic losses in poultry farming in Madagascar and many other countries. Previously, vaccines based on attenuated or inactivated Newcastle disease viruses (NDV) have been effective against this disease. However, their efficacy has declined due to viral mutations over time. To address this, two new multi-epitope vaccines (MEV) have been designed using immunoinformatics methods. First, 26 conserved epitopes from the fusion protein and 22 from the hemagglutinin-neuraminidase protein of 12 NDV strains isolated in Madagascar were selected to design the MEV. These epitopes were fused with specific linkers. Additionally, the adjuvant Avian Beta-Defensins-1 and the 6xHis tag were added to the N- and C-terminal ends of the vaccine formulations, respectively. Th

SUBMITTER: Randriamamisolonirina NT 

PROVIDER: S-EPMC11800045 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature