Perineal Wound Closure Using Gluteal Turnover Flap After Abdominoperineal Resection for Rectal Cancer: The BIOPEX-2 Randomized Clinical Trial.

ABSTRACT:

Importance

Perineal wound complications are common following abdominoperineal resection for rectal cancer and might have substantial and long-lasting implications for patients' recovery.

Objective

To evaluate the superiority of gluteal turnover flap closure compared to primary closure in patients with rectal cancer undergoing abdominoperineal resection.

Design, setting, and participants

The BIOPEX-2 study was an investigator-initiated, parallel-group, multicenter randomized clinical trial conducted at 19 centers in the Netherlands and the UK between June 2019 and November 2023, including 12 months of follow-up. Data analysis was performed from October 2023 to December 2023. Independent perineal wound assessors were masked to the type of closure. Eligibility criteria w

SUBMITTER: Kreisel SI 

PROVIDER: S-EPMC11800121 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature