Salt Substitution and Recurrent Stroke and Death: A Randomized Clinical Trial.

ABSTRACT:

Importance

The direct effect of consumption of salt substitutes on recurrent stroke and mortality among patients with stroke remains unclear.

Objective

To evaluate the effects of salt substitutes vs regular salt on the incidence of recurrent stroke and mortality among patients with stroke.

Design, setting, and participants

The Salt Substitute and Stroke Study (SSaSS), an open-label, cluster randomized clinical trial, was conducted in 600 northern Chinese villages (clusters). Patients who self-reported a hospital diagnosis of stroke were included in this prespecified subgroup analysis. Data were analyzed from November 2023 to August 2024.

Interventions

Participants were assigned to use either a salt substitute, consisting of 75% sodium chloride and 25% potassium

SUBMITTER: Ding X 

PROVIDER: S-EPMC11800127 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature