Analysis of nuclear receptor expression in head and neck cancer.

ABSTRACT:

Objective

Studies of squamous cell carcinoma of the head and neck (HNSCC) have demonstrated the importance of nuclear receptors and their associated coregulators in the development and treatment of HNSCC. We sought to characterize members of the nuclear receptor super family through interrogation of RNA-Seq and microarray data.

Materials and methods

TCGA RNA-Seq data within the cBioportal platform comparing HNSCC samples (n = 515 patients with RNA-Seq data) to normal tissue (n = 82 patients) was interrogated for significant differences in nuclear receptor expression. Affymetrix microarray analysis of HNSCC tumors relative to normal oral mucosa (41 tumor, 13 normal) was analyzed.

Results

Of the 48 NR genes and 19 NR cofactors examined, 99 % of tumor samples in the TCGA

SUBMITTER: Mortensen L 

PROVIDER: S-EPMC11800142 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature