Cytomorphology and clinicopathologic correlation of TFE3-rearranged renal cell carcinoma.

ABSTRACT:

Background

TFE3-rearranged renal cell carcinoma (TFE3-rRCC) harbors gene fusions involving TFE3 with one of many different partner genes. Because of their diverse morphologies, the differential diagnosis is broad and challenging. Publications focusing on the cytomorphology of TFE3-rRCC are sparse.

Methods

Fifteen cytology cases of TFE3-rRCC from 12 patients were retrieved, comprising seven primary kidney cases and eight metastatic cases.

Results

Cytology smears showed tumor cells with moderate granular or vacuolated cytoplasm, arranged in diverse patterns, such as three-dimensional clusters, nested/sheeted formations, isolated cells, papillary, and tubular/acinar structures. The tumor cells exhibited enlarged eccentric, round or oval nuclei, possibly situated peripher

SUBMITTER: Hou T 

PROVIDER: S-EPMC11800173 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature