Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative ¹⁵O-PET method in patients with arteriovenous malformations.

ABSTRACT: To effectively treat cerebral arteriovenous malformations (AVMs), peri-nidal flow regulation and metabolic status must be understood. In this study, we used ¹⁵O-oxygen positron emission tomography (PET) post-processing analysis to investigate vascular radioactivity in the nidal region of AVMs. Single-dynamic PET imaging was performed on seven unruptured AVM patients during the sequential inhalation of ¹⁵O₂ and C¹⁵O₂. A previously validated dual-tracer basis function method (DBFM) was employed to calculate parametric images. The results of our study were as follows. First, in remote and contralateral AVM regions, DBFM and a previous approach of dual-tracer autoradiography (DARG) showed strong positive correlations in cerebral blood flow

SUBMITTER: Maruyama D 

PROVIDER: S-EPMC11800276 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature