Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes.

ABSTRACT:

Introduction

Although genetic testing for hereditary cancers is increasing, data on health attitudes based on genetic pathogenicity are limited. This cohort study aims to establish three subcohorts based on genetic testing results to assess the health impact of genetic variations. This study evaluates changes in participant quality of life (QoL), unmet needs and mental health over time based on their genetic variant status.

Methods and analysis

This prospective cohort study will recruit 1435 patients with suspected hereditary cancer who have undergone BRCA1/2 or next-generation sequencing (NGS) testing. The study began in July 2023 and will continue until December 2027. By 2026, participants will be surveyed up to four times annually during their outpatient visits. Th

SUBMITTER: Kim JK 

PROVIDER: S-EPMC11800292 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature