Cytochrome P450 3A gene family and medication in childhood nephrotic syndrome: An update.

ABSTRACT:

Background

Nephrotic syndrome (NS) is a renal disease characterized by excessive proteinuria (greater than 3.5 g/dl per 24 h), which results in hypoalbuminemia and leads to hyperlipidemia, edema, and various complications. NS patients typically respond to standard steroid treatment (prednisolone) and are classified as having steroid-sensitive nephrotic syndrome (SSNS). However, patients who do not respond to steroid therapy after 4 weeks are referred to as having steroid-resistant nephrotic syndrome (SRNS). The unequal response to steroid treatment in nephrotic syndrome involved many factors, including genetic, medication, and kidney diseases. The CYP3A gene family is predominantly involved in the metabolism of medications used in the treatment of NS.

Methodology

A sy

SUBMITTER: Kochuthakidiyel Suresh P 

PROVIDER: S-EPMC11800309 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature