The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs.

ABSTRACT:

Background

Inner ear disorders, such as EH, commonly lead to hearing loss and vestibular dysfunction. EH is particularly prevalent in various inner ear diseases, including Meniere's disease. We aimed to evaluate the effects of EH on WAI and OAEs.

Objective

This study explores the potential of wideband acoustic immittance (WAI) and otoacoustic emissions (OAEs) for the early detection of changes in acoustic transmission associated with vasopressin-induced endolymphatic hydrops (EH) in a guinea pig model.

Methods

We induced EH in guinea pigs via daily intraperitoneal injections of arginine vasopressin over 14 consecutive days. Auditory function was assessed using Auditory Brainstem Responses (ABR), while changes in sound energy transmission were measured using WAI and Di

SUBMITTER: Lin H 

PROVIDER: S-EPMC11800357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature