Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue.

ABSTRACT: The distribution and bioaccumulation of environmental pollutants are essential to understanding their toxicological mechanism. However, achieving spatial resolution at the subtissue level is still challenging. Perfluorooctanesulfonate (PFOS) is a persistent environmental pollutant with widespread occurrence. The bioaccumulation behavior of PFOS is complicated by its dual affinity for phospholipids and protein albumin. It is intriguing to visualize the distribution preference of PFOS and investigate the differential microenvironment responses at a subtissue level. Herein, we developed a mass-spectrometry (MS)-based spatial multiomics workflow, integrating matrix-assisted laser desorption/ionization MS imaging, laser microdissection, and liquid chromatography MS analysis. This integrated wor

SUBMITTER: Shi R 

PROVIDER: S-EPMC11800377 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature