Assessing the Efficacy of Pyrolysis-Gas Chromatography-Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood.

ABSTRACT: Humans are constantly exposed to micro- and nanosized plastics (MNPs); however, there is still limited understanding of their fate within the body, partially due to limitations with current analytical techniques. The current study assessed the appropriateness of pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) analysis for the quantification of a range of polymers in human blood. An extraction protocol that reduced matrix interferences (false positives) of polyethylene (PE) and polyvinyl chloride (PVC) was developed and validated. Extraction recoveries ranged 7-109%, although surface-modified polystyrene (carboxylated) increased nanoparticle recoveries from 17 to 52%. Realistic detection limits were calculated for each polymer, accounting for matrix suppression and extraction reco

SUBMITTER: Rauert C 

PROVIDER: S-EPMC11800385 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature