Breakthrough Invasive Mold Infections in Hematologic Cases: Relevance of the Host's Factors.

ABSTRACT:

Background

Breakthrough invasive mold infections (bIMIs) are life-threatening complications in hematologic cases. Most previous studies in this field covered the whole spectrum of fungal pathogens, including yeasts, and antifungal agents.

Methods

We conducted a retrospective study including all hematologic cases of patients diagnosed with a bIMI while receiving a mold-active antifungal agent at our center between January 2017 and June 2022.

Results

Overall 37 patients were diagnosed with bIMI: 6 (16.2%) proven, 18 (48.6%) probable, and 13 (35.1%) possible. The highest incidence rate was found for micafungin (1.31 bIMI episodes per 1000 treatment-days), although with no significant differences across antifungal agents. Most patients (90.9%) for whom therapeutic drug mo

SUBMITTER: Rodriguez-Goncer I 

PROVIDER: S-EPMC11800478 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature