Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives.

ABSTRACT:

Background

Because of their many bioactivities, which include psychoanalytic, antifungal, antihypertensive, anti-inflammatory, and antiviral properties, pyrazoles and their derivatives are attracting interest in pharmacology and medicine, the pressing need for novel fungicides is increased for lessened by the growing microbiological resistance of illnesses to recognized antibiotics.

Objective

The current work validates the results and pyrazole binding sites as potent antifungals by investigating many pyrazole derivatives as antifungal agents. The biocompatibility was assessed using an HFB4 normal human skin cell line.

Methods

The biocompatibility was evaluated using an HFB4 normal human skin cell line and the findings of pyrazole binding sites were confirmed using mol

SUBMITTER: Abd-Elhalim BT 

PROVIDER: S-EPMC11800497 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature