Interactions between ABC gene polymorphisms and processing speed in predicting depression severity.

ABSTRACT:

Background

ABC family genes encode ATP-binding cassette proteins, which are involved in the transport of various substances and are associated with major depressive disorder (MDD); however, their clinical significance in MDD remains unclear. Therefore, this study aimed to investigate whether ABC family genes are associated with cognitive function, and the combined effects of genes and cognitive function on the severity of depression.

Method

Linear models or logistic regression models were used to investigate the associations of ABC family gene variants with clinical symptoms and cognitive function in 805 MDD patients (12-65 years old) and 1493 age-matched healthy controls (HCs). Seven single nucleotide polymorphisms (rs28401781, rs4148739, rs3747802, rs1109866, rs1109867, rs

SUBMITTER: Jin M 

PROVIDER: S-EPMC11800503 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature